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Structure, Physicochemical and Biological Properties of an Aqua (2,2′,2′′-Nitrilotriacetato)-oxidovanadium(IV) Salt with 4-Methylpyridinium Cation
Abstrakt
The crystal structure of a nitrilotriacetate (nta) oxidovanadi-um(IV) salt with 4-methylpyridinium cation, [4-Me(Py)H]+, of [4-Me(Py)H][VO(nta)(H2O)] stoichiometry was determined. The com-plex comprises a discrete mononuclear [VO(nta)(H2O)]–coordinationentity that can be rarely found among other known compounds con-taining nitrilotriacetate oxidovanadium(IV) moieties. The complex wascharacterized by spectroscopic (IR and EPR) methods, magnetic mea-surements, and thermogravimetry (TG-FTIR). The stability of the titlecompound in aqueous solutions was investigated by using the potentio-metric titration method. Furthermore, spectrophotometric (UV/Vis)studies have revealed that the compound is capable to scavenge the superoxide free radicals (O2•–) as well as stable organic radicals i.e.2,2⬘-azinobis(3-ethylbenzothiazoline-6 sulfonic acid) cation radical(ABTS+•) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•). Finally,biological properties of the complex studied were investigated in rela-tion to its cytoprotective activity against the oxidative damage gener-ated exogenously by using hydrogen peroxide in the HT22 hippocam-pal neuronal cell line (the MTT assay). Additionally, the biologicalaction of the compound towards two human osteosarcoma HOS andMG-63 cell lines (the MTT and BrdU tests) as well as the untrans-formed human osteoblast hFOB 1.19 cell line was tested.
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Autorzy (9)
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Dariusz Wyrzykowski
- Faculty of ChemistryUniversity of Gdan´sk
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Julia Kłak
- Faculty of ChemistryWrocław University
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Kowalski Szymon
- Department of Medical ChemistryMedical University of Gdan´sk
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Iwona Inkielewicz-Stępniak
- Department of Medical ChemistryMedical University of Gdan´sk
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Joanna Drzeżdżon
- Faculty of ChemistryUniversity of Gdan´sk
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Dagmara Jacewicz
- Faculty of ChemistryUniversity of Gdan´sk
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Lech Chmurzyński
- Faculty of ChemistryUniversity of Gdan´sk
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuł w czasopiśmie wyróżnionym w JCR
- Opublikowano w:
-
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
nr 643,
wydanie 7,
strony 501 - 510,
ISSN: 0044-2313 - Język:
- angielski
- Rok wydania:
- 2017
- Opis bibliograficzny:
- Tesmar A., Wyrzykowski D., Kazimierczuk K., Kłak J., Szymon K., Inkielewicz-Stępniak I., Drzeżdżon J., Jacewicz D., Chmurzyński L.: Structure, Physicochemical and Biological Properties of an Aqua (2,2′,2′′-Nitrilotriacetato)-oxidovanadium(IV) Salt with 4-Methylpyridinium Cation// ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE. -Vol. 643, iss. 7 (2017), s.501-510
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1002/zaac.201700022
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 116 razy
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