Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives - Publikacja - MOST Wiedzy

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Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives

Abstrakt

New conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl groups possessing forms. The obtained results were also discussed in terms of selectivity index, defined as SI = IC50/EC50.

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Michał Prejs, Grzegorz Cholewiński, Piotr Trzonkowski, Agata Kot-Wasik, Krystyna Dzierzbicka. (2018). Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives, -. https://doi.org/10.1080/10286020.2018.1451521

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
Język:
angielski
Rok wydania:
2018
Opis bibliograficzny:
Prejs M., Cholewiński G., Trzonkowski P., Kot-Wasik A., Dzierzbicka K.: Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives// JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. -, (2018), s.-

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