Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives - Publikacja - MOST Wiedzy

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Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives

Abstrakt

New conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl groups possessing forms. The obtained results were also discussed in terms of selectivity index, defined as SI = IC50/EC50.

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH nr 21, strony 178 - 185,
ISSN: 1028-6020
Język:
angielski
Rok wydania:
2019
Opis bibliograficzny:
Prejs M., Cholewiński G., Trzonkowski P., Kot-Wasik A., Dzierzbicka K.: Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives// JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH -Vol. 21,iss. 2 (2019), s.178-185
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/10286020.2018.1451521
Weryfikacja:
Politechnika Gdańska

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