The role of bile salts in digestion - Publikacja - MOST Wiedzy


The role of bile salts in digestion


Bile salts (BS) are bio-surfactants present in the gastrointestinal tract (GIT) that play a crucial role in the digestion and absorption of nutrients. The importance of BS for controlled release and transport of lipid soluble nutrients and drugs has recently stimulated scientific interest in these physiological compounds. BS are so-called facial amphiphiles showing a molecular structure that is very distinct from classical surfactants. This peculiar molecular structure facilitates the formation of dynamic aggregates able to solubilise and transport lipid soluble compounds. The detergent nature of BS has been studied in the literature, mostly concentrating on the self-assembly behaviour of BS in solution but also in relation to protein denaturation and its effect on improving proteolysis. In contrast, the affinity of BS for hydrophobic phases has received less attention and studies dealing directly with the interfacial behaviour of BS are very limited in the literature. This is despite the fact that the interfacial activity of BS plays a vital role in fat digestion since it is closely involved with lypolisis. BS adsorb onto fat droplets and can remove other materials such as proteins, emulsifiers and lipolysis products from the lipid surface. The unusual surface behaviour of BS is directly related to their intriguing molecular structure and further knowledge could provide an improved understanding of lipid digestion. This review aims to combine the new insights gained into the surface properties of BS and their role in digestion. A better understanding of surface activity of BS would allow manipulation of physico-chemical and interfacial properties to modulate lipid digestion, improve bioavailability of lipid soluble nutrients and reduce absorption of saturated fats, cholesterol and trans fats.


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Autorzy (4)

  • Zdjęcie użytkownika  Julia Maldonado-Valderrama

    Julia Maldonado-Valderrama

  • Zdjęcie użytkownika  Pete Wilde

    Pete Wilde

  • Zdjęcie użytkownika dr hab. inż. Adam Macierzanka

    Adam Macierzanka dr hab. inż.

  • Zdjęcie użytkownika  Alan Mackie

    Alan Mackie

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Informacje szczegółowe

Publikacja w czasopiśmie
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
ADVANCES IN COLLOID AND INTERFACE SCIENCE nr 165, wydanie 1, strony 36 - 46,
ISSN: 0001-8686
Rok wydania:
Opis bibliograficzny:
Maldonado-Valderrama J., Wilde P., Macierzanka A., Mackie A.: The role of bile salts in digestion// ADVANCES IN COLLOID AND INTERFACE SCIENCE. -Vol. 165, iss. 1 (2011), s.36-46
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.cis.2010.12.002
Politechnika Gdańska

wyświetlono 11 razy

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