Utilization of oriented crystal growth for screening of aromatic carboxylic acids cocrystallization with urea - Publikacja - MOST Wiedzy

Wyszukiwarka

Utilization of oriented crystal growth for screening of aromatic carboxylic acids cocrystallization with urea

Abstrakt

The possibility of molecular complex formation in the solid state of urea with benzoic acid analogues was measured directly on the crystallite films deposited on the glass surface using powder X-ray diffractometry (PXRD). Obtained solid mixtures were also analyzed using Fourier transform infrared spectroscopy (FTIR). The simple droplet evaporation method was found to be efficient, robust, fast and cost-preserving approach for first stage cocrystal screening. Additionally, the application of orientation effect to cocrystal screening simplifies the analysis due to damping of majority of diffraction signals coming from coformers. During validation phase the proposed approach successfully reproduced both positive cases of cocrystallization (urea:salicylic acid and urea:4-hydroxy benzoic acid) as well as pairs of co-formers immiscible in the solid state (urea:benzoic acid and urea:acetylsalicylic acids). Based on validated approach new cocrystals of urea were identified in complexes with 3-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 2,6-dihydroxybenzoic acid and 3,5-dihydroxybenzoic acid. In all cases formation of multicomponent crystal phase was confirmed by the appearance of new reflexes on the diffraction patterns and FTIR absorption band shifts of O–H and N–H groups.

Cytowania

  • 1 1

    CrossRef

  • 1 0

    Web of Science

  • 1 0

    Scopus

Autorzy (5)

  • Zdjęcie użytkownika  Dorota Ziółkowska

    Dorota Ziółkowska

  • Zdjęcie użytkownika  Mirosław Kobierski

    Mirosław Kobierski

  • Zdjęcie użytkownika  Karina Mroczyńska

    Karina Mroczyńska

  • Zdjęcie użytkownika  Piotr Cysewski

    Piotr Cysewski

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
Publikacja w czasopiśmie
Opublikowano w:
Journal of Crystal Growth nr 433, strony 128 - 138,
ISSN: 00220248
Rok wydania:
2016
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.jcrysgro.2015.10.015
Weryfikacja:

wyświetlono 10 razy

Publikacje, które mogą cię zainteresować

Meta Tagi