Rok 2024

• Development of a small-molecule epigenetic regenerative therapy. Subcutaneous administration of alginate formulations with high loads of zebularine and retinoic acid promotes tissue growth, vascularization and innervation and induces extensive epigenetic repatterning

  Publikacja

  • P. Słonimska
  • J. Baczyński-Keller
  • R. Płatek
  • M. Deptuła
  • M. Dzierżyńska
  • J. Sawicka
  • O. Król
  • P. Sosnowski
  • M. Koczkowska
  • A. Kostecka... i 9 innych

  - Rok 2024

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Rok 2023

• Microscopic Imaging to Visualize the Distribution of Dietary Nucleic Acids in Food Products of Various Origins

  Publikacja

  • A. Kościelak
  • Z. Koziara
  • A. Pons Maria
  • R. Płatek
  • A. Bartoszek-Pączkowska

  - Foods - Rok 2023

  Dietary nucleic acids (dietNAs) are being increasingly recognized as important food components with nutritional value. However, the precise dietary recommendations for dietNAs are limited, because established methods for determining the quantity and nutritional role of dietNAs are still lacking. One of the tools to narrow this gap could be microscopic imaging, as a convenient approach to visualize the abundance and distribution...

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Rok 2022

• Impaired Generation of Transit-Amplifying Progenitors in the Adult Subventricular Zone of Cyclin D2 Knockout Mice

  Publikacja

  • R. Płatek
  • P. Rogujski
  • J. Mazuryk
  • M. Wiśniewska
  • L. Kaczmarek
  • A. Czupryn

  - Cells - Rok 2022

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• Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

  Publikacja

  • P. Sosnowski
  • P. Sass
  • P. Słonimska
  • R. Płatek
  • J. Kamińska
  • J. Baczyński-Keller
  • P. Mucha
  • G. Peszyńska-Sularz
  • A. Czupryn
  • M. Pikuła... i 5 innych

  - Pharmaceuticals - Rok 2022

  The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...

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Rok 2021

• PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke

  Publikacja

  • J. Mazuryk
  • I. Puchalska
  • K. Koziński
  • M. J. Ślusarz
  • J. Ruczyński
  • P. Rekowski
  • P. Rogujski
  • R. Płatek
  • M. B. Wiśniewska
  • A. Piotrowski... i 7 innych

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2021

  Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...

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Rok 2020

• Imunofan - RDKVYR peptide - stimulates skin cell proliferation and promotes tissue repair

  Publikacja

  • R. Płatek

  - MOLECULES - Rok 2020

  Regeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical...

• L1 Cell Adhesion Molecule Overexpression Down Regulates Phosphacan and Up Regulates Structural Plasticity-Related Genes Rostral and Caudal to the Complete Spinal Cord Transection

  Publikacja

  • R. Płatek

  - JOURNAL OF NEUROTRAUMA - Rok 2020

  L1 cell adhesion molecule (L1CAM) supports spinal cord cellular milieu after contusion and compression lesions, contributing to neuroprotection, promoting axonal outgrowth, and reducing outgrowth-inhibitory molecules in lesion proximity. We extended investigations into L1CAM molecular targets and explored long-distance effects of L1CAM rostral and caudal to complete spinal cord transection (SCT) in...

Rok 2014

• The impact of training and neurotrophins on functional recovery after spinal cord transection: cellular and molecular mechanisms contributing to motor improvement

  Publikacja

  • R. Płatek

  - ACTA NEUROBIOLOGIAE EXPERIMENTALIS - Rok 2014

  Beneficial effects of locomotor training on the functional recovery after complete transection of the spinal cord indicate that in chronic spinal animals spontaneous recovery processes are enhanced and shaped by the training. The mechanisms of that use-dependent improvement are still not fully understood. This review tackles three aspects of this issue: (1) neurochemical attributes of functional improvement...

Rok 2008

• Actions of a nitric oxide donor on prostaglandin production and angiogenic activity in the equine endometrium

  Publikacja

  • R. Płatek

  - REPRODUCTION FERTILITY AND DEVELOPMENT - Rok 2008

  Nitric oxide (NO) plays an important role in prostaglandin secretion and angiogenesis in the reproductive system. In the present study, the roles of the NO donor spermine NONOate and tumour necrosis factor-alpha (TNF; as a positive control) in prostaglandin production and angiogenic activity of equine endometria during the oestrous cycle were evaluated. In addition, the correlation between NO production...

Rok 2007

• Endometrial nitric oxide production and nitric oxide synthases in the equine endometrium: Relationship with microvascular density during the estrus cycle

  Publikacja

  • R. Płatek

  - DOMESTIC ANIMAL ENDOCRINOLOGY - Rok 2007

  Nitric oxide (NO) plays an important role in angiogenesis and in the regulation of the blood flow. This study was carried out to investigate (i) the effects of endogenous estrogens and progestins and exogenous progesterone (P(4)) (5 ng/ml or 1 microg/ml) or estradiol 17beta (E(2)beta) (50 pg/ml or 1 microg/ml) on in vitro endometrial NO synthesis; (ii) the presence of different isoforms of NO synthase;...