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• Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases

  Publikacja

  • A. Łęgowska
  • D. Dębowski
  • Ł. Rafał
  • M. Wysocka
  • C. Czaplewski
  • A. Lesner
  • K. Rolka

  - BIOORGANIC & MEDICINAL CHEMISTRY - Rok 2010

  Fourteen monocyclic analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds were synthesized by the solid-phase method. The purpose of this work was to establish the role of a disulfide bridge present in inhibitor's side chains of Cys3 and Cys11 in association with serine proteinases. This cyclic fragment was replaced by the disulfide bridges formed by L-pencillamine (Pen), homo-L-cysteine (Hcy), N-sulfanylethylglycine...

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