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• New clicked full agonists of the estrogen receptor β

  Publikacja

  • S. Demkowicz
  • K. Filipiak
  • M. Maslyk
  • J. Ciepielski
  • S. de Pascual-Teresa
  • S. Martín-Santamaría
  • B. De Pascual-Teresa
  • A. Ramos

  - RSC Advances - Rok 2013

  A click chemistry approach was used to synthesize a series of 1,4-diaryl-substituted 1,2,3-triazoles designed to behave as estrogen receptor (ER) ligands. We studied their affinities for both receptors α and β, their agonist activities in a cell-based luciferase reporter assay and their effect on the proliferation of the hormone-dependent MCF-7 cell line. We found two compounds (3a and 3c) that behave as selective full agonists...

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