Wyniki wyszukiwania dla: HOMOSERINE DEHYDROGENASE

• Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase

  Publikacja

  • A. S. Skwarecki
  • M. Schielmann
  • D. Martynow
  • M. Kawczyński
  • A. Wiśniewska
  • M. J. Milewska
  • S. Milewski

  - JOURNAL OF PEPTIDE SCIENCE - Rok 2018

  The antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...

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