Wyniki wyszukiwania dla: INVERSE AGONIST

• (4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB1 Receptor Inverse Agonist from the Class of Benzhydryl Piperazine Analogs

  Publikacja

  • M. M. Mahmoud
  • T. Olszewska
  • H. Liu
  • D. M. Shore
  • D. P. Hurst
  • P. H. Reggio
  • D. Lu
  • D. A. Kendall

  - MOLECULAR PHARMACOLOGY - Rok 2015

  Some inverse agonists of cannabinoid receptor type 1 (CB1) have been demonstrated to be anorectic antiobesity drug candidates. However, the first generation of CB1 inverse agonists, represented by rimonabant (SR141716A), otenabant, and taranabant, are centrally active, with a high level of psychiatric side effects. Hence, the discovery of CB1 inverse agonists with a chemical scaffold distinct from these holds promise for developing...

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