Wyniki wyszukiwania dla: bicoumarin thiophosphates

• Synthesis of bicoumarin thiophosphate derivatives as steroid sulfatase inhibitors

  Publikacja

  • S. Demkowicz
  • W. Kozak
  • M. Daśko
  • M. Masłyk
  • B. Gielniewski
  • J. Rachoń

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Rok 2015

  Based on the frameworks of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c] chromen-6-one, a series of bicoumarin thiophosphate analogs have been synthesized and biologically evaluated. Additionally, their binding modes have been modeled using docking techniques. The inhibitory properties of the synthesized compounds...

  Pełny tekst do pobrania w serwisie zewnętrznym