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The Influence of Antitumor Unsymmetrical Bisacridines on 3D Cancer Spheroids Growth and Viability
PublikacjaThe culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe the ability of four UAs—C-2028, C-2041, C-2045, and C-2053—to influence the growth of HCT116 and H460 spheres and the viability of HCT116...
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3D spheroid culture system of HCT116 colon and A549 lung cancer cells in the study of the cellular response induced by antitumor unsymmetrical bisacridines in these cells.
Publikacja3D spheroid culture is a promising tool in cancer research, especially in drug development and testing. Here, the effects of antitumor unsymmetrical bisacridines (UAs) on 3D spheroids of HCT116 colon and A549 lung cancer cells were studied. The influence of four UAs: C-2028, C-2041, C-2045 and C-2053 on the morphology, size and viability of A549 cells was tested and compared with the results obtained for HCT116 cells [Kulesza J....
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Effects of unsymmetrical bisacridines on the spherical culture system of HCT116 colon and H460 lung cancer cell lines.
Publikacja3D-spheroid cultures are receiving increasing attention in cancer research, as they serve as a link between simplified 2D monolayer culture structure and the highly complex nature of tumors in vivo. Therefore, spherical cultures are a good model for the effective testing of anticancer drugs. Unsymmetrical bisacridines (UAs) are new antitumor compounds, patented in Europe and in the USA. Here, two cancer cell lines: colon HCT116...
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