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Wyniki wyszukiwania dla: OXYSTEROLS
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Wyniki wyszukiwania dla: OXYSTEROLS
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Dabigatran: its protective effect against endothelial cell damage by oxysterol
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Rivaroxaban protects from the oxysterol-induced damage and inflammatory activation of the vascular endothelium
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Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model
PublikacjaResearch indicates a role for EBI2 receptor in remyelination, demonstrating that its deficiency or antagonism inhibits this process. However, activation of EBI2 with its endogenous ligand, oxysterol 7α,25-dihydroxycholesterol (7α,25OHC), does not enhance remyelination beyond the levels observed in spontaneously remyelinating tissue. We hypothesized that the short half-life of the natural ligand might explain this lack of beneficial...