Wyniki wyszukiwania dla: Pharmaceutical cocrystals
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Pharmaceutical Patent Analyst
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SA Pharmaceutical Journal
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Infarma - Pharmaceutical Sciences
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SAUDI PHARMACEUTICAL JOURNAL
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ScienceRise: Pharmaceutical Science
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Egyptian Pharmaceutical Journal
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Determination of pharmaceuticals in fish: method optimization and occurrence in different species from Mediterranean rivers
PublikacjaThe multi-residue analytical method developed, based on accelerated solvent extraction, gel permeation chromatography purification and UPLC-MS/MS analysis allowed the simultaneous determination of 21 pharmaceuticals. Recoveries obtained for most of the target compounds were higher than 50%. The application of UPLC-MS/MS operating in the MRM mode, with two transitions monitored for each compound, provided good sensitivity and selectivity....
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Selected analytical challenges in the determination of pharmaceuticals in drinking/marine waters and soil/sediment samples
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Determination of solvents residues in vegetable oils and pharmaceuticals by headspace analysis and capillary gas chromatography.
PublikacjaPrzedstawiono wyniki zastosowania techniki analizy fazy nadpowierzchniowej w połączeniu z kapilarną chromatografią gazową do oznaczania wybranych rozpuszczalników organicznych w próbkach olejów jadalnych i produktów farmaceutycznych. Oznaczane rozpuszczalniki to: benzen, toluen, heksan oraz chlorowcopochodne węglowodorów alifatycznych. Opracowaną procedurę poddano walidacji. Wyznaczono granicę wytrzymalności, oznaczalności, liniowość...
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Microscopic and Spectroscopic Imaging and Thermal Analysis of Acrylates, Silicones and Active Pharmaceutical Ingredients in Adhesive Transdermal Patches
PublikacjaDermal or transdermal patches are increasingly becoming a noteworthy alternative ascarriers for active pharmaceutical ingredients (APIs), which makes their detailed physicochemical evaluation essential for pharmaceutical development. This paper demonstrates mid-infrared (FTIR) and Raman spectroscopy with complementary microscopic methods (SEM, optical and confocal Raman microscopy) and differential scanning calorimetry...
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Environmental aspects of using gas chromatography for determination of pharmaceutical residues in samples characterized by different composition of the matrix
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The application of single drop extraction technique for chromatographic determination of solvent residues in edible oils and pharmaceutical products
PublikacjaW pracy przedstawiono zalety i wady techniki ekstrakcji do pojedynczej kropli, będącą prostą i tanią alternatywą dla mikroekstrakcji do fazy stacjonarnej. Ponadto opisano dwie analityczne procedury do chromatograficznego oznaczania wybranych rozpuszczalników organicznych (heksanu, benzenu, toluenu oraz trichlorometanu, 1,1,1-trichloroetanu, tetrachlorometanu, trichloroetylenu, tetrachloroetenu)w olejach jadalnych i próbkach farmaceutycznych....
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Microscopic and Spectroscopic Imaging and Thermal Analysis of Acrylates, Silicones and Active Pharmaceutical Ingredients in Adhesive Transdermal Patches
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Synthesis and properties of CaFe2As2 single crystals
PublikacjaOpisana została synteza i podstawowe właściwości fizyczne monokryształów CaFe2As2. CaFe2As2 krystalizuje w strukturze ThCr2Si2, stałe sieciowe wynoszą odpowiednio: a = 3.887(4) A and c = 11.758(23) A.
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Liquid Crystals in Analytical Chemistry: A Review
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Journal of Pharmaceutics
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Determination of twenty pharmaceutical contaminants in soil using ultrasound-assisted extraction with gas chromatography-mass spectrometric detection
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Treatment innovation using solar/UV In book: The Treatment of Pharmaceutical Wastewater: Innovative Technologies and the Adaptation of Treatment Systems
PublikacjaSince ancient times, sunlight irradiation has been widely used for water purification. Apart from solar water disinfection techniques, UV irradiation is of particular interest when considering the photodegradation of various classes of emerging pollutants. Pharmaceutically active compounds are one of the largest classes of micropollutants. The main sources of these contaminants in wastewater and aqueous environments are households,...
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Deep eutectic solvent based method for analysis of Niclosamide in pharmaceutical and wastewater samples – A green analytical chemistry approach
PublikacjaThe paper presents a simple, but very effective and sensitive spectrophotometric method for trace analysis of Niclosamide based on liquid–liquid microextraction using deep eutectic solvents (DESs) prior to its quantification. Here, different DES systems, such as Choline chloride (ChCl) + Urea, ChCl + Citric acid, ChCl + Ethylene glycol and ChCl + Phenol, were synthesized and evaluated at different molar ratios, selecting ChCl + Phenol...
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Static renewal and continuous-flow calibration of two types of passive samplers for the monitoring of pharmaceuticals in wastewater
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Limitations of Integrative Passive Samplers as a Tool for the Quantification of Pharmaceuticals in the Environment – A Critical Review with the Latest Innovations
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A Holistic Approach to Determining Stereochemistry of Potential Pharmaceuticals by Circular Dichroism with β-Lactams as Test Cases
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Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae
PublikacjaPharmaceuticals and analogs of bisphenol A (BPA) are increasingly threatening environmental pollutants. In this study, mixtures of selected pharmaceuticals (diclofenac sodium salt, chloramphenicol, oxytetracycline hydrochloride, fluoxetine hydrochloride, estrone, ketoprofen, progesterone, gemfibrozil and androstenedione) were prepared with BPA and its two analogs (namely, bisphenols F and S) at such ratios to reflect environmentally...
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Analytical procedures for quality control of pharmaceuticals in terms of residual solvents content: Challenges and recent developments
PublikacjaResidual solvents play an important role in the synthesis of drugs and in product formulations. In addition, they pose a serious problem, that is toxicity, as many of them exhibit toxic or environmentally hazardous properties. Therefore, constant monitoring of quality control is needed. In this study, we present an overview of regulatory and general methods described by various pharmacopoeias. Then, the most commonly used methodologies...
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Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally relevant pharmaceuticals
PublikacjaAssessment of the impact of pharmaceutical residues on living organisms is a very complex subject. Apart from taking into account the toxicity of individual compounds, environmental factors should also be taken into account. In this paper, attempts were made to assess the impact of coexisting inorganic ions and changes in pH on the toxicity of ten selected pharmaceuticals. Two bioassays were used to measure the estrogenic and androgenic...
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Spatial distribution of pharmaceuticals in conventional wastewater treatment plant with Sludge Treatment Reed Beds technology
PublikacjaPharmaceutical residues are an emerging environmental problem. It is strongly confirmed that pharmaceuticals are present in soils and environmental waters (surface, marine and even groundwater), and that wastewater treatment plant (WWTP) effluents are the main source of pharmaceuticals in the watershed. The aim of this studywas to recognize the spatial distribution and seasonal changes of selected pharmaceuticals in conventional WWTP...
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Closing the loop: Upcycling secondary waste materials into nanoarchitectured carbon composites for the electrochemical degradation of pharmaceuticals
PublikacjaIn this study, we demonstrated the application of electrochemical oxidation as a safer and cleaner technology for minimizing the impact of pharmaceuticals in wastewaters, simultaneously mediated by upcycled secondary waste materials (SWMs)-derived electrodes, to further reduce their environmental impact. The modularity, scalability, ease of operation and reliability make electrochemical oxidation an ideal process for the destruction...
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Self-assembly of secondary aryl amides in cocrystals with perfluoroaryl coformers: structural analysis and synthon preferences
PublikacjaCooperation of aryl⋯perfluoroaryl stacking interactions and hydrogen bonds was utilized in the construction of six novel cocrystals of aromatic cis-amides with pentafluorobenzoic acid (pfba) and pentafluorophenol (pfp). They were obtained by crystallization from solution and structurally characterized. In four instances, the components form heterotetrameric motifs, in which amide:amide homodimer interacts symmetrically on two sides...
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Interplay between Aryl···Perfluoroaryl and Hydrogen Bonding Interactions in Cocrystals of Pentafluorophenol with Molecules of Trigonal Symmetry
PublikacjaCocrystals of seven star-shaped triaryl compounds with pentafluorophenol (pfp) were prepared and structurally characterized by the single-crystal X-ray diffraction method. Cocrystallization of pfp with planar (or almost planar) compounds gave six 3:1 molecular complexes with well-defined layered structures. The layers are composed of alternating pfp3 trimers, linked by hydrogen bonding, and triaryl molecules held together in planes...
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Pharmaceuticals Policy and Law
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Biuletyn Wydziału Farmaceutycznego Warszawskiego Uniwersytetu Medycznego
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Application of the PASSIL technique for the passive sampling of exemplary polar contaminants (pharmaceuticals and phenolic derivatives) from water
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Phototransformation of three selected pharmaceuticals, naproxen, 17α-Ethinylestradiol and tetracycline in water: Identification of photoproducts and transformation pathways
PublikacjaTransformation products (TPs) may be formed during various processes, however, it was proved that one of the main mechanisms responsible for degradation of pharmaceuticals in natural waters is photolysis. Three compounds were selected, tetracycline (TC), 17-α-ethinylestradiol (EE2) and naproxen (NAP), for degradation experiments which were performed using a xenon lamp emitting light with a spectrum closely approximating that of...
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Novel composite of Zn/Ti-layered double hydroxide coupled with MXene for the efficient photocatalytic degradation of pharmaceuticals
PublikacjaIn the present study, a hybrid photocatalyst of Zn/Ti layered double hydroxide (LDH) coupled with MXene – Ti3C2 was synthesized for the first time and applied in photocatalytic degradation of acetaminophen and ibuprofen, two commonly present in the natural environment and prone to accumulate in the aquatic ecosystem pharmaceuticals. The effect of MXene content (0.5 wt%, 2.5 wt%, and 5 wt%) on the photocatalytic activity of LDH/MXene...
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Acta Pharmaceutica Hungarica
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Acta Pharmaceutica Sciencia
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Surface studies of twinned of YBa2Cu3O7−δ crystals
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Growth and characterization of PrBa2Cu3O7-δ single crystals
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Calculation of vibrational spectra for cyanobiphenyl liquid crystals
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Liquid crystals thermography for technical and biomedical application
PublikacjaW artykule opisano termografię ciekłokrystaliczną jako technikę wykorzystu-jącą termochromatyczne ciekłe kryształy do badań technicznych i biomedycz-nych. W szczególności dotyczy to badań wymiany ciepła i masy, chorób skór-nych i podobnych. Praca zawiera ilustracje z badań przeprowadzonych przezautorów.
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CURRENT PHARMACEUTICAL BIOTECHNOLOGY
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Analysis of chiral pharmaceutical residues in influent and effluent samples at racemic and enantiomeric level using liquid chromatography-tandem mass spectrometry
PublikacjaIn this work, two different chromatographic methods for seasonal monitoring of pharmaceutical residue in wastewater samples were developed. In the case of enantiomeric separation of selected compounds, LC-MS technique combining with vancomycin based chiral stationary phase was used. The performance of chiral analysis enabled to monitor the pharmaceutical contamination at the enantiomeric level. The d-SPE procedure was developed...
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Investigating COVID-19 active pharmaceutical ingredients (APIs) degradation using Peroxydisulfate/FeMnOx binary metal oxide/Ultrasound System
PublikacjaDegradation of Favipiravir using a hybrid system of peroxydisulfate, FeMnOx binary metal oxide, and ultrasound irradiation was studied. A novel catalyst was synthesized with deep eutectic solvent (DES). The effects of DES type on catalytic performance was evaluated and the catalysts were characterized using XRD, SEM, BET, XPS, and EDS. DES-based catalysts exhibited higher efficiency due to structure change, surface area enhancement...
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Impact of humic acids, temperature and stirring on passive extraction of pharmaceuticals from water by trihexyl(tetradecyl)phosphonium dicyanamide
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Evaluation of the Possibility of Using Hydroponic Cultivations for the Removal of Pharmaceuticals and Endocrine Disrupting Compounds in Municipal Sewage Treatment Plants
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Matrix effects and recovery calculations in analyses of pharmaceuticals based on the determination of β-blockers and β-agonists in environmental samples
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Analysis of multi-class pharmaceuticals in fish tissues by ultra-high-performance liquid chromatography tandem mass spectrometry
PublikacjaA new sensitive method based on pressurized liquid extraction (PLE) and purification by gel permeation chromatography (GPC) prior to ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS) was developed for the determination in fish homogenate, liver and muscle of twenty pharmaceuticals compounds and metabolites from seven commonly used therapeutic families. An extensive matrix effect evaluation...
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Pharmaceuticals and another groups of emerging contaminants: Occurrence and sources in Admiralty Bay (King George Island, Maritime Antarctica)
PublikacjaEveryday live activities may introduce a wide range of chemicals into wastewater systems. In this study presence of selected types of pharmaceuticals from cardiovascular system group, nervous and muscolo-skeleton system group, antimicrobial agents, genitourinary and sex hormones were tested in the wastewater from H. Arctowski Antarctic station. Moreover, the receiver of discharged wastewater (Admiralty Bay) were also studied. Considering...
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Development of headspace solid-phase microextraction-gas chromatography method for the determination of solvent residues in edible oils and pharmaceuticals
PublikacjaW pracy przedstawiono wyniki opracowania procedury oznaczania pozostałości rozpuszczalników organicznych w olejach jadalnych z wykorzystaniem techniki HS-SPME na etapie izolacji i wzbogacania analitów. Przedstawiono proces optymalizacji etapu izolacji i rozdzielenia związków. Dla każdego z analitów wyznaczono parametry walidacyjne charakteryzujące procedurę tj. granice wykrywalności, granicę oznaczalności, liniowość, zakres pomiarowy,...
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Brazilian Journal of Pharmaceutical Sciences
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