Wyszukiwarka
dr hab. Sławomir Makowiec
Zatrudnienie
- Profesor nadzwyczajny ze stop. nauk. dr hab. w Katedra Chemii Organicznej
Media społecznościowe
Kontakt
- mak@pg.edu.pl
Profesor nadzwyczajny ze stop. nauk. dr hab.
- Miejsce pracy
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Budynek A Wydz. Chemii
pokój 111 otwiera się w nowej karcie - Telefon
- (58) 347 2883
- mak@pg.edu.pl
Wybrane publikacje
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The stereoselective formation of β-lactams with acyl ketenes generated from 5-acyl-Meldrum's acids
Acyl ketenes formed during thermal decompositions of 5-acyl-2,2-dimethyl-1,3-dioxa-4,6-diones undergo stereoselective [2+2] cycloaddition to chiral aldimines. We report the first example of optically active 3-acyl-β-lactams formation from Meldrum’s acid derivatives.
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New thiourea organocatalysts and their application for the synthesis of 5-(1H-indol-3-yl)methyl-2,2-dimethyl-1,3-dioxane-4,6-diones a source of chiral 3-indoylmethyl ketenes
The stereoselective properties of modified thiourea organocatalysts were tested in the Friedel–Crafts alkylation of indole with 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6-diones, which produces chiral 5-((1H-indol-3-yl)(aryl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-diones. Based on a tentative reaction mechanism for ((S)-N-benzyl-2-(3-(3,5-bis (trifluoromethyl)phenyl)thioureido)-N,3,3-trimethylbutanamide organocatalysts, modifications...
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Practical Method for the Preparation of 2,2-Dimethyl-5- {aryl[(hetero)aryl]methyl}-1,3-dioxane-4,6-diones: Synthesis and Mechanistic Study
An efficient practical synthetic procedure has been developed for the synthesis of 2,2-dimethyl-5-{aryl[(hetero)aryl]methyl}- 1,3-dioxane-4,6-diones through Friedel–Crafts alkylation. The scope and limitation of the reaction of 2,2-dimethyl-5-arylidene-1,3-dioxane- 4,6-diones with π-excess aromatic systems have been delineated.
Uzyskane stopnie/tytuły naukowe
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2013-12-10
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2003-09-29
wyświetlono 280 razy