Joanna Zielińska - Publications - Bridge of Knowledge

Joanna Zielińska

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Year 2016

Membrane Sterols Modulate the Binding Mode of Amphotericin B without Affecting Its Affinity for a Lipid Bilayer
Publication
- A. Neumann
- M. Wieczór
- J. Zielińska
- M. Bagiński
- J. Czub
- LANGMUIR - Year 2016
Membrane-active antibiotics are known to selectively target certain pathogens based on cell membrane properties, such as fluidity, lipid ordering, and phase behavior. These are in turn modulated by the composition of a lipid bilayer and in particular by the presence and type of membrane sterols. Amphotericin B (AmB), the golden standard of antifungal treatment, exhibits higher activity toward ergosterol-rich fungal membranes, which...

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