Julia Pakuła - Publications - Bridge of Knowledge

Julia Pakuła

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PhD Student at Gdansk University of Technology

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Publications

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total: 2

Year 2025

The interactions of Pu22 G-quadruplex, derived from c-MYC promoter sequence, with antitumor acridine derivatives – an NMR/MD combined study
Publication
- T. Laskowski
- M. Kosno
- W. Andrałojć
- J. Pakuła
- R. Stojałowski
- J. Borzyszkowska-Bukowska
- E. Paluszkiewicz
- Z. Mazerska
- Molecular Therapy-Nucleic Acids - Year 2025
Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents that exhibit significant antitumor activity against a wide range of cancer cell lines and solid tumors in vivo. UAs consist of two different acridine-based ring systems, which are connected by an aminoalkyl linker. Recent studies have demonstrated that UAs can suppress the c-MYC protooncogene, which is overexpressed in many tumor types. As a proposed...

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Year 2024

NMR-Based Structural Insight into DNA G-Quadruplex
Publication
- J. Pakuła
- Year 2024
Emerging as a promising area in anticancer research, noncanonical DNA structures such as G-quadruplexes are studied using NMR spectroscopy. NOESY spectra reveals crucial interactions between ligands and G-quadruplexes, helping to understand non-covalent binding mechanisms. This knowledge is essential for rational drug design targeting these structures.

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