Magdalena Płotka - Publications - Bridge of Knowledge

Magdalena Płotka

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Year 2022

A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism
Publication
- M. Szadkowska
- M. Olewniczak
- A. Kloska
- E. Jankowska
- M. Kapusta
- B. Rybak
- D. Wyrzykowski
- W. Zmudzinska
- A. Gieldon
- A. Kocot... and 5 others
- Microbiology Spectrum - Year 2022
This work reports detailed characteristics of the antimicrobial peptide Intestinalin (P30), which is derived from the LysC enzyme of Clostridium intestinale strain URNW. The peptide shows a broader antibacterial spectrum than the parental enzyme, showing potent antimicrobial activity against clinical strains of Gram-positive staphylococci and Gram-negative pathogens and causing between 3.04 ± 0.12 log kill for Pseudomonas aeruginosa...

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