Marta Jancz - Publications - Bridge of Knowledge

Marta Jancz

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Year 2021

Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
Publication
- J. Lica
- M. Wieczór
- G. J. Grabe
- M. Heldt
- M. Jancz
- M. Misiak
- K. Gucwa
- W. Brankiewicz
- N. Maciejewska
- A. Stupak... and 4 others
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2021
Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...

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