Nikola Radoń - Publications - Bridge of Knowledge

Nikola Radoń

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Year 2023

The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies
Publication
- T. Laskowski
- M. Kosno
- W. Andrałojć
- J. Frąckowiak
- J. Borzyszkowska-Bukowska
- P. Szczeblewski
- N. Radoń
- M. Świerżewska
- A. Woźny
- E. Paluszkiewicz
- Z. Mazerska
- Scientific Reports - Year 2023
Members of a novel class of anticancer compounds, exhibiting high antitumor activity, i.e. the unsymmetrical bisacridines (UAs), consist of two heteroaromatic ring systems. One of the ring systems is an imidazoacridinone moiety, with the skeleton identical to the structural base of Symadex. The second one is a 1-nitroacridine moiety, hence it may be regarded as Nitracrine’s structural basis. These monoacridine units are connected...

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