Search results for: androgen receptor

• Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells

  Publication

  • M. Niemira
  • B. Borowa-Mazgaj
  • S. B. Bader
  • A. Moszyńska
  • M. Ratajewski
  • K. Karaś
  • M. Kwaśniewski
  • A. Krętowski
  • Z. Mazerska
  • E. M. Hammond
  • A. Skwarska

  - Biomedicines - Year 2020

  Androgen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...

  Full text available to download

• Desmoid type fibromatosis - Male, 35 - Tissue image [10040729541207421]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Myofibroblastoma - Male, 68 - Tissue image [5160730021345241]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Leydig cell tumor of ovary, NOS - Female, 50 - Tissue image [3300730006074211]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Duct carcinoma, NOS - Male, 63 - Tissue image [5300730025894421]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of PAROTID GLANID tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leydig cell tumor of testis, NOS - Male, 29 - Tissue image [4120730022884841]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Apocrine adenocarcinoma - Female, 70 - Tissue image [6130730026844961]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.