Search results for: ANTITUMOR ACRIDINONES - Bridge of Knowledge

Search results for: ANTITUMOR ACRIDINONES

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Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
Publication
- M. Pawłowska
- R. Chu
- B. Fedejko-Kap
- E. Augustin
- Z. Mazerska
- A. Radominska-Pandya
- T. C. Chambers
- DRUG METABOLISM AND DISPOSITION - Year 2013
The acridinone derivates C-1305 and C-1311 are promising antitumor agents with high activity against several experimental cellular and tumor models and which are under evaluation in pre-clinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both compounds were conjugated by several UGT isoforms with the most active being extrahepatic UGT1A10. The present studies were designed to test...

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