Search results for: 5-HT1A

• Pharmacophore models based studies on the affinity and selectivity toward 5-HT1A with reference to α1-adrenergic receptors among arylpiperazine derivatives of phenytoin

  Publication

  • J. Handzlik
  • E. Szymańska
  • K. Nędza
  • M. Kubacka
  • A. Siwek
  • S. Mogilski
  • J. Handzlik
  • B. Filipek
  • K. Kieć-Kononowicz

  - BIOORGANIC & MEDICINAL CHEMISTRY - Year 2011

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• Serotonergic–Muscarinic Interaction within the Prefrontal Cortex as a Novel Target to Reverse Schizophrenia-Related Cognitive Symptoms

  Publication

  • P. Cieślik
  • A. Radulska
  • G. Burnat
  • L. Kalinowski
  • J. M. Wierońska

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2021

  Recent studies revealed that the activation of serotonergic 5-HT1A and muscarinic M1, M4, or M5 receptors prevent MK-801-induced cognitive impairments in animal models. In the present study, the effectiveness of the simultaneous activation of 5-HT1A and muscarinic receptors at preventing MK-801-induced cognitive deficits in novel object recognition (NOR) or Y-maze tests was investigated. Activators of 5-HT1A (F15599), M1 (VU0357017),...

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