Search results for: CYCLOADITION

• The stereoselective formation of β-lactams with acyl ketenes generated from 5-acyl-Meldrum's acids

  Publication

  • A. Zakaszewska
  • E. Najda-Mocarska
  • S. Makowiec

  - NEW JOURNAL OF CHEMISTRY - Year 2016

  Acyl ketenes formed during thermal decompositions of 5-acyl-2,2-dimethyl-1,3-dioxa-4,6-diones undergo stereoselective [2+2] cycloaddition to chiral aldimines. We report the first example of optically active 3-acyl-β-lactams formation from Meldrum’s acid derivatives.

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