Search results for: CYP1A1, CYP1B1

• Modulation of CYP1A1, CYP1A2 and CYP1B1 expression by cabbage juices and indoles in human breast cell lines

  Publication

  • H. Szaefer
  • B. Licznerska
  • V. Krajka-Kuźniak
  • A. Bartoszek-Pączkowska
  • W. Baer-Dubowska

  - NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL - Year 2012

  Epidemiological studies have shown that consumption of cab- bage and sauerkraut is connected with significant reduction of breast cancer incidences. Estrogens are considered a major breast cancer risk factor and their metabolism by P450 enzymes substan- tially contributes to carcinogenic activity. The aim of this study was to investigate the effect of cabbage and sauerkraut juices of differ- ent origin on the expression profile...

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• Cabbage Juices and Indoles Modulate the Expression Profile of AhR, ERα, and Nrf2 in Human Breast Cell Lines

  Publication

  • H. Szaefer
  • V. Krajka-Kuźniak
  • B. Licznerska
  • A. Bartoszek-Pączkowska
  • W. Baer-Dubowska

  - NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL - Year 2015

  Our previous studies showed the diversified effect of cabbage juices and indoles on the estrogen metabolism key enzymes (CYP1A1, CYP1A2, CYP1B1) in breast epithelial cells differing in ER status, i.e., in tumorigenic—MCF7, MDA-MB-231 and non-tumorigenic—MCF10A cells. The aim of the present study was to further investigate the mechanism of chemopreventive action of cabbage juice and its active components by evaluating their effect...

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