Search results for: DNA DAMAGE

• Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition

  Publication

  • V. Ćurčić
  • M. Olszewski
  • N. Maciejewska
  • A. Višnjevac
  • T. Srdić-rajić
  • V. Dobričić
  • A. T. García-sosa
  • S. B. Kokanov
  • J. B. Araškov
  • R. Silvestri... and 4 others

  - ARCHIV DER PHARMAZIE - Year 2024

  Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...

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• Interactions of telomeric proteins with nucleic acids: sequence recognition on intact and oxidatively damaged telomeres

  Publication

  • M. Wieczór

  - Year 2019

  Telomeres are complex nucleoprotein assemblies that play a vital role in the maintenance of functional ends of linear chromosomes. Telomeric DNA, composed of tandem repeats of the 5'-TTAGGG-3' motif, solves the so-called end replication problem: as chromosomes shorten with each cell division, no information is lost, and the telomere can be re-extended. In the cell, many protein factors regulate telomere length, nuclear positioning...

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