Search results for: GUV

• A BODIPY‐Based Molecular Rotor in Giant Unilamellar Vesicles: A Case Study by Polarization‐Resolved Time‐Resolved Emission and Transient Absorption Spectroscopy

  Publication

  • K. K. Jha
  • A. Prabhakaran
  • L. Spantzel
  • R. C. Sia
  • I. Pérez
  • R. A. Arellano-Reyes
  • A. Elmanova
  • A. Dasgupta
  • C. Eggeling
  • M. Börsch... and 4 others

  - ChemPhotoChem - Year 2023

  BODIPY and BODIPY-derived systems are widely applied as fluorophores and as probes for viscosity detection in solvents and biological media. Their orientational and rotational dynamics in biological media are thus of vital mechanistic importance and extensively investigated. In this contribution, polarization-resolved confocal microscopy is used to determine the orientation of an amphiphilic BODIPY-cholesterol derivative in homogeneous...

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• Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics

  Publication

  • E. Grela
  • M. Wieczór
  • R. Luchowski
  • J. Zielinska
  • A. Barzycka
  • W. Grudzinski
  • K. Nowak
  • P. Tarkowski
  • J. Czub
  • W. Gruszecki

  - MOLECULAR PHARMACEUTICS - Year 2018

  Amphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortunately, the pharmacological applicability of this drug is limited because of its severe toxic side effects. At the same time, the lack of a well-defined mechanism of selectivity hampers the efforts to rationally design safer derivatives. As the drug primarily targets the biomembranes of both fungi and humans, new insights into the...

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