Search results for: INTESTINALIN

• A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism

  Publication

  • M. Szadkowska
  • M. Olewniczak
  • A. Kloska
  • E. Jankowska
  • M. Kapusta
  • B. Rybak
  • D. Wyrzykowski
  • W. Zmudzinska
  • A. Gieldon
  • A. Kocot... and 5 others

  - Microbiology Spectrum - Year 2022

  This work reports detailed characteristics of the antimicrobial peptide Intestinalin (P30), which is derived from the LysC enzyme of Clostridium intestinale strain URNW. The peptide shows a broader antibacterial spectrum than the parental enzyme, showing potent antimicrobial activity against clinical strains of Gram-positive staphylococci and Gram-negative pathogens and causing between 3.04 ± 0.12 log kill for Pseudomonas aeruginosa...

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