Search results for: KETENS

• TMSCL as a rate accelerating additive in acylations of amines with 5-(α- amino-α'-hydroxy)methylene meldrum's acids

  Publication

  • K. Janikowska
  • S. Makowiec

  - SYNTHETIC COMMUNICATIONS - Year 2011

  Aspects are presented of the acylation of amines, alcohols and thiols with 5-(α-amino- α'-hydroxy)methylene Meldrum's acids. We placed special emphasis on the acylation reaction of secondary amines with 5-(α-amino- α'-hydroxy)methylene Meldrum's acids, which, due to their basicity, caused problems concerning salt formation with a Meldrum acid derivative. We found that secondary amines, which react at the slowest rate and with a...

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• The stereoselective formation of β-lactams with acyl ketenes generated from 5-acyl-Meldrum's acids

  Publication

  • A. Zakaszewska
  • E. Najda-Mocarska
  • S. Makowiec

  - NEW JOURNAL OF CHEMISTRY - Year 2016

  Acyl ketenes formed during thermal decompositions of 5-acyl-2,2-dimethyl-1,3-dioxa-4,6-diones undergo stereoselective [2+2] cycloaddition to chiral aldimines. We report the first example of optically active 3-acyl-β-lactams formation from Meldrum’s acid derivatives.

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