Search results for: MHC-I

• Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants

  Publication

  • W. Ezzemani
  • A. Kettani
  • S. Sappati
  • K. Kondaka
  • H. El Ossmani
  • K. Tsukiyama-Kohara
  • H. Altawalah
  • R. Saile
  • M. Kohara
  • S. Benjelloun
  • S. Ezzikouri

  - JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS - Year 2023

  The genome feature of SARS-CoV-2 leads the virus to mutate and creates new variants of concern. Tackling viral mutations is also an important challenge for the development of a new vaccine. Accordingly, in the present study, we undertook to identify B- and T-cell epitopes with immunogenic potential for eliciting responses to SARS-CoV-2, using computational approaches and its tailoring to coronavirus variants. A total of 47 novel...

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• Cancer immune escape: the role of antigen presentation machinery

  Publication

  • A. Kallingal
  • M. Olszewski
  • N. Maciejewska
  • W. Brankiewicz
  • M. Bagiński

  - JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY - Year 2023

  The mechanisms of antigen processing and presentation play a crucial role in the recognition and targeting of cancer cells by the immune system. Cancer cells can evade the immune system by downregulating or losing the expression of the proteins recognized by the immune cells as antigens, creating an immunosuppressive microenvironment, and altering their ability to process and present antigens. This review focuses on the mechanisms...

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