Search results for: MINEFRADIL

• Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.

  Publication

  • N. C. Valerie
  • B. Dziegielewska
  • A. S. Hosing
  • E. Augustin
  • L. S. Gray
  • D. L. Brautigan
  • J. M. Larner
  • J. Dziegielewski

  - BIOCHEMICAL PHARMACOLOGY - Year 2013

  Glioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...

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