Search results for: PILICYDY

• Pilicides effectively hinder chaperone-usher interactions in all Gram-negative bacteria

  Publication

  • J. Pilipczuk
  • B. Zalewska-Piątek
  • K. Dzierzbicka
  • S. Makowiec
  • R. Piątek
  • A. Cyrancka-Czaja

  - Year 2012

  The chaperone-usher pathway of adhesive structures biogenesis is highly conserved in all Gram-negative bacteria. Pili are polymers of thousands protein subunits that possess conserved immunoglobuline-like structure denoted by lack of the seventh G strand. The effect of this structural defect is a hydrophobic acceptor cleft. The folding of protein subunits is strictly dependent on the action of specific periplasmic chaperone protein...

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