Search results for: RETROTUFTSIN

• Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma

  Publication

  • M. Cichorek
  • A. Ronowska
  • M. Gensicka-Kowalewska
  • M. Deptula
  • I. Pelikant-Malecka
  • K. Dzierzbicka

  - JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY - Year 2019

  PURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....

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• Synthesis of functionalized new conjugates of batracylin with tuftsin/ retro-tuftsin derivatives and their biological evaluation

  Publication

  • W. Januchta
  • M. Serocki
  • K. Dzierzbicka
  • G. Cholewiński
  • A. Składanowski

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Year 2015

  New batracylin conjugates with tuftsin/retro-tuftsin derivatives were designed and synthesized using T3P as a coupling agent. The conjugates possess an amide bond formed between the carboxyl group of heterocyclic molecule and the N-termini of the tuftsin/retro-tuftsin chain. The in vitro cytotoxic activity of the new analogues and their precursors was evaluated using a series of human and murine tumor cells. BAT conjugates containing...

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