Search results for: allostery

• Allosteric regulation of cathepsins and procathepsins enzymatic activity by glycosaminoglycans and their mimetics

  Projects

  Project manager: dr Krzysztof Bojarski   Financial Program Name: SONATINA

  Project realized in Department of Physical Chemistry according to UMO-2023/48/C/ST4/00163 agreement from 2023-12-01

• Establishing the allosteric mechanism in CRISPR‐Cas9

  Publication

  • Ł. Nierzwicki
  • P. R. Arantes
  • A. Saha
  • G. Palermo

  - Wiley Interdisciplinary Reviews-Computational Molecular Science - Year 2021

  Allostery is a fundamental property of proteins, which regulates biochemical information transfer between spatially distant sites. Here, we report on the critical role of molecular dynamics (MD) simulations in discovering the mechanism of allosteric communication within CRISPR‐Cas9, a leading genome editing machinery with enormous promises for medicine and biotechnology. MD revealed how allostery intervenes during at least three...

  Full text available to download

• Michał Jurkowski

  People