Search results for: anthrapyridazones

• Cell Density-Dependent Cytological Stage Profile and Its Application for a Screen of Cytostatic Agents Active Toward Leukemic Stem Cells

  Publication

  • J. J. Lica
  • G. J. Grabe
  • M. Heldt
  • M. Misiak
  • P. Bloch
  • M. Serocki
  • M. Switalska
  • J. Wietrzyk
  • M. Bagiński
  • A. Hellmann... and 2 others

  - STEM CELLS AND DEVELOPMENT - Year 2018

  Proliferation and expansion of leukemia is driven by leukemic stem cells (LSCs). Multidrug resistance (MDR) of LSCs is one of the main reasons of failure and relapses in acute myeloid leukemia (AML) treatment. In this study, we show that maintaining HL-60 at low cell culture density or applying a 240-day treatment with anthrapyridazone (BS-121) increased the percentage of primitive cells, which include LSCs determining the overall...

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