Search results for: conjugate transporters

• Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation

  Publication

  • J. Lica
  • M. Heldt
  • M. Wieczór
  • P. Chodnicki
  • N. Ptaszyńska
  • A. Łęgowska
  • W. Brankiewicz
  • K. Gucwa
  • A. Stupak
  • N. Maciejewska... and 8 others

  - MOLECULAR PHARMACOLOGY - Year 2024

  Hematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...

  Full text to download in external service