Search results for: enos uncoupling

• Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

  Publication

  • A. Janaszak-Jasiecka
  • A. Płoska
  • J. M. Wierońska
  • L. W. Dobrucki
  • L. Kalinowski

  - CELLULAR & MOLECULAR BIOLOGY LETTERS - Year 2023

  Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark of endothelial dysfunction underlying the patho‑ genesis of the cardiovascular disease. Vascular NO is synthesized by endothelial nitric oxide synthase (eNOS) from the substrate L‑arginine (L‑Arg), with tetrahydrobiopterin...

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• Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability

  Publication

  • A. Janaszak-Jasiecka
  • A. Siekierzycka
  • A. Płoska
  • I. T. Dobrucki
  • L. Kalinowski

  - Biomolecules - Year 2021

  Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of nitric oxide (NO). Thus, any factors that interfere with the synthesis or metabolism of NO in endothelial cells are involved in CVD pathogenesis. It is well established that hypoxia is both the triggering factor as well as the accompanying factor...

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