Search results for: neuroprotection

• PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke

  Publication

  • J. Mazuryk
  • I. Puchalska
  • K. Koziński
  • M. J. Ślusarz
  • J. Ruczyński
  • P. Rekowski
  • P. Rogujski
  • R. Płatek
  • M. B. Wiśniewska
  • A. Piotrowski... and 7 others

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2021

  Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...

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• L1 Cell Adhesion Molecule Overexpression Down Regulates Phosphacan and Up Regulates Structural Plasticity-Related Genes Rostral and Caudal to the Complete Spinal Cord Transection

  Publication

  • R. Płatek

  - JOURNAL OF NEUROTRAUMA - Year 2020

  L1 cell adhesion molecule (L1CAM) supports spinal cord cellular milieu after contusion and compression lesions, contributing to neuroprotection, promoting axonal outgrowth, and reducing outgrowth-inhibitory molecules in lesion proximity. We extended investigations into L1CAM molecular targets and explored long-distance effects of L1CAM rostral and caudal to complete spinal cord transection (SCT) in...