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Search results for: LYSOSOMAL CONTENT
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Genistein: a lysosomal stimulator for treatment of various lysosomal diseases
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Combined Therapies for Lysosomal Storage Diseases
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Introducing the concept of Decisional DNA-Based web content mining
PublicationPrzedstawiono koncepcje zastosowania struktury reprezentacji wiedzy opartej na decyzyjnym DNA w procesie wyszukiwania informacji w internecie. Dokonano analizy eksperymentow tak wspomaganego wyszukiwania oraz sformulowano wnioski na temat przyszlych badan prowadzacych do dalszej integracji procesu wyszukiwania z doswiadczeniami zdobytymi w trakcie tego wyszukiwania.
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublicationMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
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ECONTENT
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Factors and processes modulating phenotypes in neuronopathic lysosomal storage diseases
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THE AGRI-HOOD AND SLOW-SUBURB CONCEPT IN THE CONTEXT OF AN IN-BETWEEN CITY (ZWISCHENSTADT)
PublicationThe concept of an “in-between-city” (Zwischenstadt) interprets the urban sprawl in Europe as a new, evolving model of urban development, taking the form of urbanized landscapes, which does not correspond with the traditional understanding of urban design. The actual shape of an in-between-city reflects the today’s technology and economy generating new lifestyles: global trends coexist with the locality in a strong relation. The...
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The molecular mechanism of genistein action in lysosomal storage diseases: A transcriptomic approach
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The dying medium temperature impact on the final moisture content of pine wood at constant drying time
PublicationThe results of final moisture content of pine wood (Pinus sylvestris L.) after drying process are presented. The wood in the experiments was taken from the northern part of Pomeranian region in Poland. The drying process was performed in the experimental chamber equipped with the micro-jet heat exchanger. The air at temperatures of 40°C, 60°C, 80°C, 100°C and 120°C with relative humidity about 60% and atmospheric pressure was the...
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Data, Information, Knowledge, Wisdom Pyramid Concept Revisited in the Context of Deep Learning
PublicationIn this paper, the data, information, knowledge, and wisdom (DIKW) pyramid is revisited in the context of deep learning applied to machine learningbased audio signal processing. A discussion on the DIKW schema is carried out, resulting in a proposal that may supplement the original concept. Parallels between DIWK pertaining to audio processing are presented based on examples of the case studies performed by the author and her collaborators....