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Instytut Chemii Organicznej i Żywnościowej

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Catalog Publications

Year 1987
  • Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
    Publication
    • M. Tomasz
    • R. Lipman
    • D. Chowdary
    • J. Pawlak
    • G. L. Verdine
    • K. Nakanishi

    - SCIENCE - Year 1987

    A DNA cross-link adduct of the antitumor agent mitomycin C (MC) to DNA has been isolated and characterized; the results provide direct proof for bifunctional alkylation of DNA by MC. Exposure of MC to Micrococcus luteus DNA under reductive conditions and subsequent nuclease digestion yielded adducts formed between MC and deoxyguanosine residues. In addition to the two known monoadducts, a bisadduct was obtained. Reductive MC activation...