Search
Prof dr hab Adam Lesner
Employment
- 1995 - present professor at Chemistry
Publications
Filters
total: 116
Catalog Publications
Year 2016
-
PEGylated substrates of NSP4 protease: A tool to study protease specificity
Publication -
Substrate profiling of Zika virus NS2B‐NS3 protease
Publication -
The LD loop as an important structural element required for transmission of the allosteric signal in the HtrA (DegP) protease from Escherichia coli
Publication
Year 2015
-
Analysis of the Link between the Redox State and Enzymatic Activity of the HtrA (DegP) Protein from Escherichia coli
Publication -
Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice
Publication -
Conformational studies of [Nphe5]SFTI-1 by means of 2D NMR spectroscopy in conjunction with molecular dynamics calculations
Publication -
Design and synthesis of new substrates of HtrA2 protease
Publication -
Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains
Publication -
Synthesis and Evaluation of Biological Activity of Antimicrobial – Pro-Proliferative Peptide Conjugates
Publication
Year 2014
-
Cathepsin G activity lowers plasma LDL and reduces atherosclerosis
Publication -
Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor
Publication -
Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1
Publication -
New Selective Peptidyl Di(chlorophenyl) Phosphonate Esters for Visualizing and Blocking Neutrophil Proteinase 3 in Human Diseases
Publication -
Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro
Publication -
Substrate specificity of human matriptase-2
Publication -
Synthesis of Novel Phosphonic‐Type Activity‐Based Probes for Neutrophil Serine Proteases and Their Application in Spleen Lysates of Different Organisms
Publication -
The LA Loop as an Important Regulatory Element of the HtrA (DegP) Protease from Escherichia coli
Publication -
Ultrasensitive internally quenched substrates of human cathepsin L
Publication
Year 2013
-
A new proteinase 3 substrate with improved selectivity over human neutrophil elastase
Publication -
Adrenal Secretory Protease
Publication -
Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus
Publication -
Hybrid analogues of SFTI-1 modified in P1 position by β- and γ-amino acids and N-substituted β-alanines
PublicationA series of compounds containing either non-proteinogenic beta-/gamma-amino acids or N-substituted beta-alanine residues (beta-peptoid units) in P-1 specificity position were synthesized based on the structure of sunflower trypsin inhibitor 1 (SFTI-1). The compounds were synthesized on a solid support; the N-substituted beta-alanines (beta Nhlys and beta Nhphe) were introduced into a peptidomimetic chain via a two-step approach...
-
Inhibitors of cathepsin G: a patent review (2005 to present)
Publication -
Microarrays and Dynamics of Fluorescent Dyes
Publication -
Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis)
Publication -
Temperature-induced changes of HtrA2(Omi) protease activity and structure
Publication
Year 2012
-
Editorial(Hot Topic: Proteolysis in Health and Disease)
Publication -
Future of Protease Activity Assays
Publication -
Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin
PublicationA series of linear and cyclic fragments and analogs of two peptides (OGTI and HV-BBI) isolated from skin secretions of frogs were synthesized by the solid-phase method. Their inhibitory activity against several serine proteinases: bovine beta-trypsin, bovine alpha-chymotypsin, human leukocyte elastase and cathepsin G from human neutrophils, was investigated together with evaluation of their antimicrobial activities against Gram-negative...
-
Pegylated Fluorescent Peptides as Substrates of Proteolytic Enzymes
Publication -
Reporter Fluorescent Molecules in Biological Systems: The Current Overview
Publication -
Substrate specificity of Staphylococcus aureus cysteine proteases – Staphopains A, B and C
Publication -
Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: Development and applications
Publication -
Three Wavelength Substrate System of Neutrophil Serine Proteinases
Publication
Year 2011
-
Analogues of trypsin inhibitor SFTI-1 modified in the conserved P1′ position by synthetic or non-proteinogenic amino acids retain their inhibitory activity
PublicationA series of linear and monocyclic (with a disulfide bridge only) analogues of trypsin inhibitor SFTI-1 modified in the P-1 and/or P-1' positions were synthesized by the solid-phase method. In the substrate specificity P-1 position, Phe or N-benzylglycine (Nphe) were introduced, whereas the conserved Ser6 in Bownam-Birk (BBI) inhibitors was replaced by Hse (L-homoserine), Nhse [N-(2-hydroxyethyl)glycine], Sar, and Ala. Kinetic studies...
-
Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity
PublicationA number of monocyclic SFTI-1 analogues modified in the conserved inhibitor P1 position by Pro, its L-hydroxyproline (Hyp) derivative as well as mimetics with different ring size were synthesized by the solid-phase method. Replacement of Ser6 by Pro, Hyp, and a four-member ring, L-azetidine-2-carboxylic acid (Aze), retained trypsin or chymotrypsin inhibitory activity. The determined association equilibrium constants of these analogues...
Year 2010
-
Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges
Publication -
Highly Specific Substrates of Proteinase 3 Containing 3-(2-Benzoxazol-5-yl)-l-alanine and Their Application for Detection of This Enzyme in Human Serum
Publication -
Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases
PublicationFourteen monocyclic analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds were synthesized by the solid-phase method. The purpose of this work was to establish the role of a disulfide bridge present in inhibitor's side chains of Cys3 and Cys11 in association with serine proteinases. This cyclic fragment was replaced by the disulfide bridges formed by L-pencillamine (Pen), homo-L-cysteine (Hcy), N-sulfanylethylglycine...
-
Inhibitory activity of double‐sequence analogues of trypsin inhibitor SFTI‐1 from sunflower seeds: an example of peptide splicing
Publication -
Selection of peptomeric inhibitors of bovine α-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach
Publication -
Substrate specificity and inhibitory study of human airway trypsin-like protease
Publication -
The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region
Publication
Year 2009
-
Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells
Publication -
Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity
Publication -
Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors
Publication -
Low-Molecular-Weight Aldehyde Inhibitors of Cathepsin G
Publication
Year 2008
-
Design of selective substrates of proteinase 3 using combinatorial chemistry methods
Publication -
Designing of Substrates and Inhibitors of Bovine α-Chymotrypsin with Synthetic Phenylalanine Analogues in Position P1
Publication -
Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods
Publication
seen 1055 times