Year 2011

• New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro

  Publication

  • M. Serocki
  • M. Sabisz
  • A. Bułakowska
  • M. T. Konieczny
  • A. Pieczykolan
  • M. Głazka
  • K. Wiciejowska
  • W. Strożek
  • J. Pieczykolan
  • K. Lemke
  • A. Składanowski

  - Acta Biochimica Polonica - Year 2011

  Chalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...

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