Barbara Horowska - Publications - Bridge of Knowledge

dr inż. Barbara Horowska

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Year 2020

Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
Publication
- E. Paluszkiewicz
- B. Horowska
- B. Borowa-Mazgaj
- G. Peszyńska-Sularz
- J. Paradziej-Łukowicz
- E. Augustin
- J. Konopa
- Z. Mazerska
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Year 2020
New promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three groupsincluding 36 compounds were synthesized by the condensation of 4-nitro or 4-methylacridinone, imi-dazoacridinone and triazoloacridinone derivatives with 1-nitroacridine compounds linked with anaminoalkyl chain. Cytotoxicity screening revealed the high potency of these compounds against severaltumor cell lines. Particularly, imidazoacridinone-1-nitroacridine...

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