Year 2019

• Structural changes of a simple peptide—Trpzip-1—in aqueous solutions and the corresponding hydration phenomena under the influence of temperature

  Publication

  • P. Bruździak
  • A. Panuszko
  • B. Piotrowski
  • J. Stangret

  - JOURNAL OF MOLECULAR LIQUIDS - Year 2019

  Trpzip-1, a simple β-hairpin, is a rare example of peptide with stable secondary structure and can be a convenient model to study temperature-related processes that potential prion or amyloid proteins undergo. Although its sequence is simple, the exact processes which the peptide undergoes in aqueous solutions are quite complex and not well understood. The selection of well-established experimental (DSC, FTIR) and theoretical methods...

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Year 2018

• Taurine as a water structure breaker and protein stabilizer

  Publication

  • P. Bruździak
  • A. Panuszko
  • E. Kaczkowska
  • B. Piotrowski
  • A. Daghir
  • S. Demkowicz
  • J. Stangret

  - AMINO ACIDS - Year 2018

  The enhancing effect on the water structure has been confirmed for most of the osmolytes exhibiting both stabilizing and destabilizing properties in regard to proteins. The presented work concerns osmolytes, which should be classified as “structure breaking” solutes: taurine and N,N,N-trimethyltaurine (TMT). Here, we combine FTIR spectroscopy, DSC calorimetry and DFT calculations to gain an insight into the interactions between...

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