Year 2025

• Distinct cellular uptake patterns of two anticancer unsymmetrical bisacridines and their metabolic transformation in tumor cells.

  Publication

  • J. Frąckowiak
  • P. Kubica
  • M. Kosno
  • A. Potęga
  • K. Owczarek-Grzymkowska
  • J. Borzyszkowska-Bukowska
  • T. Laskowski
  • E. Paluszkiewicz
  • Z. Mazerska

  - JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS - Year 2025

  Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents. Their high cytotoxicity towards multiple human cancer cell lines and inhibition of human tumor xenograft growth in nude mice signal their potential for cancer treatment. Therefore, the mechanism of their strong biological activity is broadly investigated. Here, we explore the efflux and metabolism of UAs, as both strongly contribute to the development...

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Year 2023

• The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies

  Publication

  • T. Laskowski
  • M. Kosno
  • W. Andrałojć
  • J. Frąckowiak
  • J. Borzyszkowska-Bukowska
  • P. Szczeblewski
  • N. Radoń
  • M. Świerżewska
  • A. Woźny
  • E. Paluszkiewicz
  • Z. Mazerska

  - Scientific Reports - Year 2023

  Members of a novel class of anticancer compounds, exhibiting high antitumor activity, i.e. the unsymmetrical bisacridines (UAs), consist of two heteroaromatic ring systems. One of the ring systems is an imidazoacridinone moiety, with the skeleton identical to the structural base of Symadex. The second one is a 1-nitroacridine moiety, hence it may be regarded as Nitracrine’s structural basis. These monoacridine units are connected...

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Year 2022

• Acid–Base Equilibrium and Self-Association in Relation to High Antitumor Activity of Selected Unsymmetrical Bisacridines Established by Extensive Chemometric Analysis

  Publication

  • M. Kosno
  • T. Laskowski
  • J. Frąckowiak
  • A. Potęga
  • A. Kurdyn
  • W. Andrałojć
  • J. Borzyszkowska-Bukowska
  • K. Szwarc-Karabyka
  • Z. Mazerska

  - MOLECULES - Year 2022

  Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents previously synthesized by our group. Our recent studies have demonstrated their high antitumor potential against multiple cancer cell lines and human tumor xenografts in nude mice. At the cellular level, these compounds affected 3D cancer spheroid growth and their cellular uptake was selectively modulated by quantum dots. UAs were shown to undergo metabolic...

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Year 2021

• Potential of Silver Nanoparticles in Overcoming the Intrinsic Resistance of Pseudomonas aeruginosa to Secondary Metabolites from Carnivorous Plants

  Publication

  • M. Krychowiak-Maśnicka
  • M. Krauze-Baranowska
  • S. Godlewska
  • Z. Kaczyński
  • A. Bielicka-giełdoń
  • N. Grzegorczyk
  • M. Narajczyk
  • J. Frąckowiak (formerly: J. E. Frackowiak)
  • A. Krolicka

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2021

  Carnivorous plants are exemplary natural sources of secondary metabolites with biological activity. However, the therapeutic antimicrobial potential of these compounds is limited due to intrinsic resistance of selected bacterial pathogens, among which Pseudomonas aeruginosa represents an extreme example. The objective of the study was to overcome the intrinsic resistance of P. aeruginosa by combining silver nanoparticles (AgNPs)...

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