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Abstract
One N-methyl- and 4-substituted 2-imidazolines are described. Fluorene bisimidazolines were obtained in good yield (64-92%), starting from 2,7-dicyanofluorene and ammonium sulfide. In a two-step procedure the crude bisthioamide was reacted with excess diaminoalkane-ethanol (1:1 mixt.) in an oil bath. This new procedure is superior over std. methods. For the sake of comparison, a new triazine bisimidazoline (I) was prepd. by direct conversion of the appropriate bisnitrile. Preliminary in vitro studies have shown an interesting anticancer activity of this compd. (NSC 710607) against diverse human cancer types, including colon, CNS, melanoma, breast, non-small cell lung, and ovarian.
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- Category:
- Magazine publication
- Type:
- Magazine publication
- Published in:
-
MONATSHEFTE FUR CHEMIE
no. 137,
edition 9,
pages 1203 - 1210,
ISSN: 0026-9247 - Publication year:
- 2006
- Bibliographic description:
- Jaroslaw Spychala, A Convenient Way to Methylated 2-Imidazolines. Syntheses of Fluorene and Triazine Cyclic Diamidines, Monatshefte fuer Chemie, vol. 137(9), pages 1203-1210, 2006.
- DOI:
- Digital Object Identifier (open in new tab) https://doi.org/10.1007/s00706-006-0516-y
- Verified by:
- No verification
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