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Alternative method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)-one—a substrate for the preparation of phosphodiesterase (5) inhibitors
Abstract
Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones, as isosteres of purine, are of interest for pharmaceutical research as potential substrates for the synthesis of cGMP-PDE5 inhibitors. We present a novel, alternative method for the synthesis of imidazotriazinones, that differs from the previously reported ones with respect to the method of construction of the triazinone ring in the molecule. The key step in our approach is condensation of an appropriate a-keto-ester with amidrazones, leading to the triazinone heterocycle. Several different substituted imidazolo-triazinones have been synthesized in this manner.
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.tet.2012.11.037
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
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TETRAHEDRON
no. 69,
edition 2,
pages 474 - 480,
ISSN: 0040-4020 - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Olszewska T., Gajewska E., Milewska M.: Alternative method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)-one—a substrate for the preparation of phosphodiesterase (5) inhibitors// TETRAHEDRON. -Vol. 69, iss. 2 (2013), s.474-480
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.tet.2012.11.037
- Verified by:
- Gdańsk University of Technology
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