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Angiopoietin-like growth factor-derived peptides as biological activators of adipose-derived mesenchymal stromal cells
Abstract
Adipose-derived mesenchymal stromal cells (AD-MSCs) are an essential issue in modern medicine. Extensive preclinical and clinical studies have shown that mesenchymal stromal/stem cells, including AD-MSCs, have specific properties (ability to differentiate into other cells, recruitment to the site of injury) of particular importance in the regenerative process. Ongoing research aims to elucidate factors supporting AD-MSC culture and differentiation in vitro. Angiopoietin-like proteins (ANGPTLs), known for their pleiotropic effects in lipid and glucose metabolism, may play a significant role in this context. Regeneration is a complex and dynamic process controlled by many factors. ANGPTL6 (Angiopoietin-related growth factor, AGF), among many activities modulated the biological activity of stem cells. This study examined the influence of synthesized AGF-derived peptides, designated as AGF9 and AGF27, on AD-MSCs. AGF9 and AGF27 enhanced the viability and migration of AD-MSCs and acted as a chemotactic factor for these cells. AGF9 stimulated chondrogenesis and lipid synthesis during AD-MSCs differentiation, influenced AD-MSCs cytokine secretion and modulated transcriptome for such basic cell activities as migration, transport of molecules, and apoptosis. The ability of AGF9 to modulate the biological activity of AD-MSCs warrants the consideration of this peptide a noteworthy therapeutic agent that deserves further investigation for applications in regenerative medicine.
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Authors (12)
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Adriana Schumacher mgr
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Piotr Mucha dr hab.
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Izabela Puchalska
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Milena Deptula
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Anna Wardowska
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Agata Tymińska
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Natalia Filipowicz
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Alina Mieczkowska
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Arkadiusz Piotrowski dr hab.
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Michał Pikuła Prof. dr hab.
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Miroslawa Cichorek
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.biopha.2024.117052
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Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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BIOMEDICINE & PHARMACOTHERAPY
no. 177,
ISSN: 0753-3322 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Schumacher A., Mucha P., Puchalska I., Deptula M., Wardowska A., Tymińska A., Filipowicz N., Mieczkowska A., Sachadyn P., Piotrowski A., Pikuła M., Cichorek M.: Angiopoietin-like growth factor-derived peptides as biological activators of adipose-derived mesenchymal stromal cells// BIOMEDICINE & PHARMACOTHERAPY -Vol. 177, (2024), s.117052-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.biopha.2024.117052
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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