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Abstract
Neutralization of 2-(1-imidazole)-1-hydroxyl-1,1`-ethylidenediphosphonic acid (zoledronic acid) by an excess of ammonia yielded bis(ammonium) zoledronate dihydrate, {C5H8N2O7P2 2−, 2(H4N+), 2(H2O)}. The product is readily soluble in water and forms monocrystals for which the X-ray structural analysis was carried out. The zoledronic anion is of double negative charge due to deprotonation of three P–OH groups and protonation of the nitrogen in the imidazole ring.The structure is stabilized by extensive network of N–H⋅ ⋅ ⋅O andO–H⋅ ⋅ ⋅O hydrogen bonds expanding through the crystal in plane (002).The imidazole ring is involved in pi-pi stacking interactions with its symmetry equivalents related by inversion centers at (1 0 0) and (1 1/2 0), with distances between centroids (Cg–Cg) of 3.819 (2) and 3.881 (2) A, respectively
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- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1155/2013/741483
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- Category:
- Articles
- Type:
- artykuły w czasopismach recenzowanych i innych wydawnictwach ciągłych
- Published in:
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Journal of Applied Crystallography
no. 2013,
pages 1 - 5,
ISSN: 1600-5767 - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Sikorska M., Chojnacki J.: Bis(ammonium) Zoledronate Dihydrate// Journal of Crystallography. -Vol. 2013., nr. ID 741483 (2013), s.1-5
- DOI:
- Digital Object Identifier (open in new tab) 10.1155/2013/741483
- Verified by:
- Gdańsk University of Technology
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