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Abstract
Significance: Chemotherapy is a primary method to treat cancer, but while cytotoxic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types, including dermal cells and macrophages involved in wound healing, which often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent advances: Despite its significant impact on patients' recovery from surgery, the issue of delayed wound healing in individuals undergoing chemotherapy remains inadequately explored. Critical Issues: This review aims to analyze the harmful impact of chemotherapy on wound healing. The analysis showed that chemotherapy drugs could inhibit cellular metabolism, cell division, and angiogenesis and lead to nerve damage. They impede the migration of cells into the wound and reduce the production of extracellular matrix. At the molecular level, they interfere with replication, transcription, translation, and cell signaling. This work reviews skin problems that patients may experience during and after chemotherapy and demonstrates insights into the cellular and molecular mechanisms of these pathologies. Future directions: In the future, the problem of impaired wound healing in patients treated with chemotherapy may be addressed by cell therapies like autologous keratinocyte transplantation, which has already proved effective in this case. Epigenetic intervention to mitigate the side effects of chemotherapy is also worth considering, but epigenetic consequences of chemotherapy on skin cells are largely unknown and should be investigated.
Citations
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Authors (5)
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Jacek Zieliński dr hab.
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Marcin Skrzypski
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Michał Pikuła dr hab. med.
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1089/wound.2023.0097
- License
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Advances in Wound Care
no. 13,
pages 187 - 199,
ISSN: 2162-1918 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Słonimska P., Sachadyn P., Zieliński J., Skrzypski M., Pikuła M.: CHEMOTHERAPY-MEDIATED COMPLICATIONS OF WOUND HEALING. AN UNDERSTUDIED SIDE EFFECT// Advances in Wound Care -Vol. 13,iss. 4 (2024), s.187-199
- DOI:
- Digital Object Identifier (open in new tab) 10.1089/wound.2023.0097
- Sources of funding:
-
- IDUB
- Verified by:
- Gdańsk University of Technology
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