Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors - Publication - Bridge of Knowledge

Your account

login

Search

Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors

Abstract

The chloroacridines affect biological forms of melanoma in different ways. Amelanotic (Ab) melanoma (with inhibited melanogenesis and higher malignancy) was particularly sensitive to the action of the chloroacridines. The Ab melanoma cells died through apoptosis and through death without caspase activation. Diminished activity of TAC enzymes was noticed among Ab melanoma cells together with ATP/NAD depletion, especially in the case of 1b. Our data show that the biological forms of the tumors responded to 1a and its 4-methylated analog in different ways. 1a and 1b could be inducers of regulated melanoma cell death, especially the amelanotic form. Although the mechanism of the cell death is not fully understood, 1b may act by interfering with the TAC enzymes and blocking specific pathways leading to tumor growth. This could encourage further investigation of its anticancer activity, especially against the amelanotic form of melanoma.

Citations

  • 1

    CrossRef

  • 0

    Web of Science

  • 2

    Scopus

Authors (6)

Cite as

Full text

download paper
downloaded 97 times
Publication version
Accepted or Published Version
License
Creative Commons: CC-BY open in new tab

Keywords

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
BIOMEDICINE & PHARMACOTHERAPY no. 130,
ISSN: 0753-3322
Language:
English
Publication year:
2020
Bibliographic description:
Cichorek M., Ronowska A., Dzierzbicka K., Gensicka-Kowalewska M., Deptuła M., Pelikant-Malecka I.: Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors// BIOMEDICINE & PHARMACOTHERAPY -Vol. 130, (2020), s.110515-
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.biopha.2020.110515
Verified by:
Gdańsk University of Technology

seen 158 times

Recommended for you

Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma

2019

Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents

2019

Peptidoglycan hydrolases - potential weapons against Staphylococcus aureus

2012

Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells

2013
Meta Tags